Methodological guide addresses issues concerning the education of persons with autism. It describes the problems of autism, its definition and basic triad of the disability. Through the concrete examples it describes the development of skills and abilities of some clients: communication skills, daily living and social skills, self-realization in leisure and work area. This guide includes a description and diagnosis methodology to work with clients in different areas. It is enriched by the stories of specific clients. The catalogue of suitable tools and photographs is attached.